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Search Results for " spinal motor "

11

Compounds

Cat No. Product Name Synonyms Targets
T1030 Triprolidine hydrochloride monohydrate Triprolidine hydrochloride Histamine Receptor
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma.
T4641 Branaplam LMI 070,NVS-SM1 Others , Potassium Channel , DNA/RNA Synthesis
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.
T3336 Rg3039 PF-06687859 Others
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an...
T34399 Rovatirelin KPS-0373,S0373,S-0373,S 0373 AChE
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an...
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T35689 MTP 131 acetate Others
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...
T34664 SMN2-Stablizer-27 SMN2-Stablizer 27,SMN2 Stablizer-27
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).
T60514 Triprolidine
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3].
T35594 Cuspin-1
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative dise...
T36373 Urocortin II (mouse) (trifluoroacetate salt)
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II...
T37127 L-AP4 monohydrate L-AP4 monohydrate
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhe...
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